As a youth Krikor educated in Canada, he took courses on commercial, fashion, industrial, and furniture design. His designs earned him an acceptance at Concordia University as an applicant for an electronic engineering degree. After a design course in his major, Agopian was offered an individual exhibition, a rare event for first-year students. On witnessing his work, his professor urged him to switch to fine art.

Krikor Agopian is an artist who knows no boundaries. His canvases take us into an extraordinary universe. Designed with rigorous architectural form, Agopian’s paintings strike us with their graphic precision, the meticulous rendering of matter, the radiance of light. In Agopian’s work, the richness of colour distilled to restrained effect induces a contagious serenity.

He has held about forty individual exhibitions in Beirut, Montreal, Ottawa, Toronto, New York, and Los Angeles and participated in more than two hundred fifty group exhibitions in Canada, the United States, Europe, and he Middle East. Agopian's art work can be found in many private and public collections, museums, and art societies. Agopian is a master of the trompe-l'oeil style and the airbrush painting technique.

Agopian Krikor studied at Studio 5316 and in Concordia University, both in Montreal, Canada, and at the Washington School of Fine Arts in Washington, DC. He taught in the Beirut School of Fine Arts from 1972 to 1973, in the Lebanese Academy of Fine Arts (ALBA) from 1977 to 1981, and in the Institute of Fine Arts of the Université du Saint-Esprit de Kaslik, from 1981 to 1985.

He won the following prizes: Honory mention of the Trans Mediterranean Airways, Beirut in 1972; the prize of excellence of the Makhoul Street Art Fair in Beirut in 1980 and in 1981 the first prize; the second Grand Prix, all categories, at the National Competition of Visual Arts, Montreal in 1990 and 1991. He was nominated for the prize of Artistic Excellence Laval in 1991, and won the third Grand Prix, all categories, at the 13th National Competition of Visuals Arts in Montreal in 1996, the first prize for abstract work at the 14th International Competition of Visual Arts in Montreal in 1997, and the first trophy for surrealism at the 15th International Visual Arts, in Montreal 1998.